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The Gen3 Data Commons [1] is a platform for managing and sharing large-scale genomic and health data sets, created by the National Cancer Institute (NCI), and is released under the Apache Software License 2.0. It provides a standardized way to store and access data, as well as tools for data harmonization and analysis. The Gen3 Data Commons also includes a user-friendly interface for researchers to easily discover and access data sets, and collaborate with others.<br><br>We have integrated Gen3 with High Performance Computing (HPC) to assist users in conducting high-speed computing at National Center for High-Performance Computing, Taiwan (NCHC) [2]. Our team refined the cloud deployment procedure that was provided by the original Gen3 team, and also adopted it into NCHC cloud service successfully. We also provide a light weight deployment solution under docker compose environment to help scientists or developers to evaluate Gen3 [3-6]. Through the data protection and sharing technology of Gen3, the HPC cluster can also access data and perform analysis. The relevant integration includes Private k8s, authentication integration, storage, computing, and more.<br><br>This is a presentation to share and explain how we use Gen3 and continuously integrate it into NCHC's services, to assist researchers in related fields with data analysis through high-speed computing resources, especially for users who need to conduct large-scale data analysis projects.<br><br>Reference<br>1. <a href="https://gen3.org/" rel="nofollow" target="_blank">https://gen3.org/</a><br>2. <a href="https://www.nchc.org.tw" rel="nofollow" target="_blank">https://www.nchc.org.tw</a><br>3. <a href="https://github.com/ceasar-sun/nchc.gen3-docker-compose" rel="nofollow" target="_blank">https://github.com/ceasar-sun/nchc.gen3-docker-compose</a><br>4. <a href="https://github.com/Thomas-Tsai/cdis-manifest-nchc" rel="nofollow" target="_blank">https://github.com/Thomas-Tsai/cdis-manifest-nchc</a><br>5. <a href="https://github.com/Thomas-Tsai/ng3-manifestservice" rel="nofollow" target="_blank">https://github.com/Thomas-Tsai/ng3-manifestservice</a><br>6. <a href="https://github.com/Thomas-Tsai/ng3-cloud-automation" rel="nofollow" target="_blank">https://github.com/Thomas-Tsai/ng3-cloud-automation</a>